Applied Digital Toxicology Expert - all genders - #2184076

About the job

Our Team:

At Sanofi, computational modelling and simulation of drug safety helps us accelerate R&D for patients and supports patient safety throughout the entire research and development process. It’s about harnessing data insights and leveraging mathematical models and digital twins responsibly to search deeper and solve sooner than ever before. Join our Digital Toxicology team as Computational Systems Toxicologist and you can help make it happen. Your job? Leading, developing and applying Quantitative Systems Toxicology approaches to predict safety of proteins, antibodies, nanobodies, and synthetic molecules. Provide actionable insights to medicinal chemists, toxicologists, and clinical teams for candidate selection, lead optimization, and risk mitigation by predicting organ toxicities and safety biomarkers. Drive compound safety and further enhance decision making in discovery and development projects by working with interdisciplinary teams. At Sanofi, Digital Toxicology supports both investigative needs and critical decision making throughout all phases of drug discovery and development. As part of the Preclinical Safety unit, Digital Toxicology is linked to investigative and regulatory toxicology, pathology and safety pharmacology expertise.

Main responsibilities:

• Develop scientific methodology & strategy of mechanistic systems biology models to facilitate safety data exploration and drug safety prediction at the interface between pharmaceutical drug research and development
• Drive the analysis, integration, visualization, and interpretation of safety data to contextualize toxicological findings and generate predictive analyses
• Apply mathematical models to evaluate preclinical toxicity mitigation plan
• Collaborate with project teams in R&D and provide scientific expertise as computational toxicology expert to aid toxicology representatives in the selection and optimization of large and small molecule therapeutics
• Participate in external consortia and symposia to keep current with industry trends and regulatory evolution in the systems toxicology field; represent Sanofi interests, maintaining high ethical and scientific standards.
• Author external presentations and manuscripts to contribute to scientific advancement of the toxicology field.

About you

• Experience: Hands-on experience with mathematical models, and their application in toxicology, e.g. mechanistic systems biology models, Quantitative Systems Toxicology, digital twins. Track record and demonstrated experience in developing and validating new scientific methodologies and strategies in the field of computational toxicology.
• Soft and technical skills: Excellent data mining, analysis, integration, interrogation, and interpretation skills are essential, and application to toxicology is critical. Proficiency in mathematical modelling environment, such as MATLAB or R, and programming languages such as Python. Natural strengths in networking and communication are also essential.
• Education: PhD in applied mathematics, biomathematics, systems biology or computational biology/toxicology with knowledge in pharmaceutical drug discovery and/or toxicology

Why choose us?

• Discover the opportunity to establish new paradigms for toxicology at Sanofi and be an industry leader in the systems and translational toxicology space.
• Be part of an active, highly innovative scientific organization, having diverse opportunities to collaborate globally and be highly recognized for successes
• Bring the miracles of science to life alongside a supportive, future-focused team.
• Benefit from a well-thought-out benefits package that rewards your contribution and commitment.
• We take care of you and your family with a wide range of health and social such as high-quality healthcare, numerous prevention programs and coverage for long-term illness. Our 14-week paid family leave for both parents is outstanding as well as a wide range of childcare benefits.
• Start your career at an attractive location based in Frankfurt/Germany and experience our modern working environment and benefit from hybrid, flexible working time models.

"Using the power of Computational Toxicology, we are not just predicting drug safety—we are pioneering a future where innovative methodologies transform data into life-saving insights”
Friedemann Schmidt, Head of Digital Toxicology

Pursue Progress. Discover Extraordinary.

Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

#LI-Hybrid

#MechanicSystemsBiology

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#PursueProgress

#DiscoverExtraordinary

Pursue progress, discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visitingwww.sanofi.com or via our movie We are Sanofi